MIR-21-5P

Intervention

2 papers study it4 findings

  • 1 lab in 1 country
  • Funders: Narodowe Centrum Nauki and 2 more
  • Animals2

Outcomes

4

Bone regeneration

upin mice1

1 study
  1. MIR-21-5P increases bone regeneration in mice.

    “greater ratio of newly formed tissue after miR-21 application”

    Animalsin a critical-size cranial defect modelcranial defect site

    MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice

    Stem cell research & therapyMar 29, 2023

Stem cell differentiation

upin mouse cells1

1 study
  1. MIR-21-5P improves stem cell differentiation in mouse cells.

    “miR-21 enhanced the osteogenic differentiation of BMSCs”

    Cellsin osteoporotic BMSCs

    MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice

    Stem cell research & therapyMar 29, 2023

More on Stem cell differentiation

Mitochondrial fission and fusion

upin mouse cells1

1 study
  1. MIR-21-5P activates mitochondrial fission and fusion in mouse cells.

    “drove mitochondria dynamics in osteoporotic BMSCs evidenced by the intensification of fission processes”

    Cellsin osteoporotic BMSCs

    MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice

    Stem cell research & therapyMar 29, 2023

More on Mitochondrial fission and fusion

Cell viability

upin mouse cells1

1 study
  1. MIR-21-5P improves cell viability in mouse cells.

    “MiR-21 upregulation improved cells' viability”

    Cellsin osteoporotic BMSCs

    MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice

    Stem cell research & therapyMar 29, 2023

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