Mangiferin
- 3 independent labs in 3 countries
- Funders: Korea Ministry of Education and 5 more
- Animals1
- Model organisms1
- Cells1
Outcomes
10Cellular senescence
downin cells1downin human cells1
2 studies
Cellular senescence
downin cells1downin human cells1
Mangiferin inhibits cellular senescence in cells.
“mangiferin effectively regulates the AMPK/mTOR/IRF5 pathway, inhibits neuroinflammation mediated by microglial activation, and delays neuronal cell senescence.”
Cellsin cellular and animal models of neuronal cell senescence
IBRO neuroscience reportsApr 8, 2025
Mangiferin decreases cellular senescence in human cells.
“Following long-term exposure to HG, MAG significantly mitigated DNA damage and delayed cellular aging”
Cellsin high glucose-treated hBM-MSCs
Mechanisms of ageing and developmentJan 26, 2025
sod-3
upin worms1
1 study
sod-3
upin worms1
Mangiferin increases sod-3 in worms.
“The expression levels of hsp-16.2 and sod-3 were significantly increased”
Model organisms
Current medicinal chemistryJul 22, 2026
hsp-16.2
upin worms1
1 study
hsp-16.2
upin worms1
Mangiferin increases hsp-16.2 in worms.
“The expression levels of hsp-16.2 and sod-3 were significantly increased”
Model organisms
Current medicinal chemistryJul 22, 2026
Oxidative stress and ROS signalling
downin worms1
1 study
Oxidative stress and ROS signalling
downin worms1
Mangiferin decreases oxidative stress and ROS signalling in worms.
“Mangiferin treatment in nematodes reduced lipid droplet buildup, protein carbonyls, and reactive oxygen species (ROS)”
Model organismsnematodes
Current medicinal chemistryJul 22, 2026
Motility function
upin worms1
1 study
Motility function
upin worms1
Mangiferin improves motility function in worms.
“improved motility function in both wild-type N2 and aak2 mutant strains”
Model organismswild-type N2 and aak2 mutant strains
Current medicinal chemistryJul 22, 2026
Lifespan
upin worms1
1 study
Lifespan
upin worms1
Mangiferin extends lifespan in worms.
“Mangiferin treatment in nematodes reduced lipid droplet buildup, protein carbonyls, and reactive oxygen species (ROS), leading to longer lifespans and better survival.”
Model organismsnematodes
Current medicinal chemistryJul 22, 2026
Inflammation
downin cells1
1 study
Inflammation
downin cells1
Mangiferin inhibits inflammation in cells.
“suppress microglial activation and markedly reduce the production of pro-inflammatory cytokines by activated microglia”
Cellsin activated microglia
IBRO neuroscience reportsApr 8, 2025
Senescence-associated beta-galactosidase
downin human cells1
1 study
Senescence-associated beta-galactosidase
downin human cells1
Mangiferin decreases senescence-associated beta-galactosidase in human cells.
“reduced senescence-associated β-galactosidase staining”
Cellsin high glucose-treated hBM-MSCs
Mechanisms of ageing and developmentJan 26, 2025
Cell proliferation
upin human cells1
1 study
Cell proliferation
upin human cells1
Mangiferin increases cell proliferation in human cells.
“MAG and metformin treatment enhanced cell proliferation”
Cellsin high glucose-treated hBM-MSCs
Mechanisms of ageing and developmentJan 26, 2025
DNA damage response
downin human cells1
1 study
DNA damage response
downin human cells1
Mangiferin protects against DNA damage response in human cells.
“MAG activated AMPK and SIRT1, thus protecting against DSB-induced damage.”
Cellsin etoposide-treated hBM-MSCs
Mechanisms of ageing and developmentJan 26, 2025