Imeglimin

3 papers5 findings

PubChem 24812808

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: European Social Fund and 1 more

Animals1
Cells1

Outcomes

5

Senescence-associated beta-galactosidase

downin mouse cells1

1 study

Imeglimin decreases senescence-associated beta-galactosidase in mouse cells.
“Both agents restored the high glucose-induced downregulation of Sirt1, PGC1α, and TFAM expression and attenuated the increase in SA-β-gal-positive cells.”
Cellshigh glucose (25 mM)
Imeglimin and Nicotinamide Mononucleotide Ameliorate High Glucose–Induced Mitochondrial Dysfunction and Senescence in Schwann Cells
ADA Scientific Sessions 2026 abstract5 Jun 2026

More on Senescence-associated beta-galactosidase

NAD+

upin mouse cells1

1 study

Imeglimin increases NAD+ in mouse cells.
“Imeglimin significantly increased intracellular NAD+ levels.”
Cellshigh glucose (25 mM)
Imeglimin and Nicotinamide Mononucleotide Ameliorate High Glucose–Induced Mitochondrial Dysfunction and Senescence in Schwann Cells
ADA Scientific Sessions 2026 abstract5 Jun 2026

Mitochondrial oxidative stress

downin mouse cells1

1 study

Imeglimin decreases mitochondrial oxidative stress in mouse cells.
“Imeglimin and NMN suppressed high glucose-increases in mitochondrial oxidative stress.”
Cellshigh glucose (25 mM)
Imeglimin and Nicotinamide Mononucleotide Ameliorate High Glucose–Induced Mitochondrial Dysfunction and Senescence in Schwann Cells
ADA Scientific Sessions 2026 abstract5 Jun 2026

More on Mitochondrial oxidative stress

Infarct size

downin rats1

1 study

Imeglimin decreases infarct size in rats.
“Injection of imeglimin 24 h before simulated brain ischemia in vitro reduced infarct size only in young and middle-aged rat groups.”
Animalssimulated brain ischemia in vitrobrain24 h before
Effects of imeglimin on mitochondrial functions and ischemic brain damage in young and aging rats
Journal of pharmacological sciences10 Oct 2025

Oxidative phosphorylation

downin rat cells1

1 study

Imeglimin inhibits oxidative phosphorylation in rat cells.
“direct addition of imeglimin to mitochondria isolated from young and middle-aged rat brains suppressed oxidative phosphorylation”
Cellsisolated brain mitochondriabrain
Effects of imeglimin on mitochondrial functions and ischemic brain damage in young and aging rats
Journal of pharmacological sciences10 Oct 2025

More on Oxidative phosphorylation

Latest

2 in 12 months

ADA Scientific Sessions 2026 Abstract5 Jun

Imeglimin and Nicotinamide Mononucleotide Ameliorate High Glucose–Induced Mitochondrial Dysfunction and Senescence in Schwann Cells

Experiments in mouse cellsNicotinamide mononucleotide

Biochemistry Biokhimiia27 Dec

Suppressing Mitochondrial ROS Production is Beneficial in Multiple Preclinical Models of Human Disease

ReviewInterventions

Journal of Pharmacological Sciences16 Nov

Effects of imeglimin on mitochondrial functions and ischemic brain damage in young and aging rats

Experiments in ratsInterventions