Hysterectomy

1. Hysterectomy has no effect on dementia in humans (pooled ratio 0.94, 95% CI 0.84-1.05).

   “Hysterectomy without documented adnexal surgery was not clearly associated with dementia/AD (4 studies; pooled ratio 0.94, 95% confidence interval [CI] 0.84-1.05; I 2 = 82.2%).”

   Reviewwithout documented adnexal surgery

   Associations of Hysterectomy and Oophorectomy with Dementia Risk: A Systematic Review and Meta-Analysis of Observational Studies · Journal of clinical medicine · 17 Sep 2026

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