Hyperoxia

1. Hyperoxia decreases NFE2L2 in mice.

   “Expression of Nrf-2 showed significant downregulation in hyperoxia-treated males (p=0.001), and upregulation in hyperoxia-treated females (p=0.023).”

   Animalsbrain18-hmales

   Diminished Resistance to Hyperoxia in Brains of Reproductively Senescent Female CBA/H Mice

   Medical science monitor basic research·16 Sep 2015

2. Hyperoxia increases NFE2L2 in mice.

   “Expression of Nrf-2 showed significant downregulation in hyperoxia-treated males (p=0.001), and upregulation in hyperoxia-treated females (p=0.023).”

   Animalsbrain18-hfemales

   Diminished Resistance to Hyperoxia in Brains of Reproductively Senescent Female CBA/H Mice

   Medical science monitor basic research·16 Sep 2015

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1. Hyperoxia increases NOG in rats (threefold increase).

   “In a neonatal rat hyperoxia-induced BPD model, alveolar simplification was observed alongside a threefold increase in Noggin mRNA, a reduction of BMP4 to 30% of controls”

   Animalsin neonatal rats exposed to hyperoxiaday 14

   Hyperoxia promotes bronchopulmonary dysplasia via Noggin-mediated BMP4 antagonism and cellular senescence

   Frontiers in physiology·20 Apr 2026

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1. Hyperoxia induces senescence-associated secretory phenotype (SASP) in cells.

   “Key SASP factors, including interleukin-6, interleukin-1β, matrix metalloproteinase 12, and transforming growth factor-β1, were significantly elevated after hyperoxia exposure”

   Cellshyperoxia exposure

   Mitochondrial DNA-driven senescence-associated secretory phenotype promotes the development of bronchopulmonary dysplasia

   American journal of physiology. Cell physiology·12 Sep 2025

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1. Hyperoxia increases glycolysis in mice.

   “Metabolic switch from mitochondrial respiration to glycolysis and pentose phosphate pathway was observed in these two clusters.”

   Animalsneonatal hyperoxia (SD7 group)lung

   Characterization of hyperoxia-induced senescent lung macrophages in neonatal mice

   bioRxiv : the preprint server for biology·10 May 2025Preprint

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1. Hyperoxia induces cellular senescence in mice.

   “neonatal hyperoxia, known to lead to a BPD-like phenotype in rodent models, causes lung cellular senescence.”

   Review3-day hyperoxia modellung

   Characterization of hyperoxia-induced senescent lung macrophages in neonatal mice

   bioRxiv : the preprint server for biology·10 May 2025Preprint

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1. Hyperoxia increases mtDNA mutations in rats.

   “Mitochondrial DNA mutations were significantly higher by P90 and associated with significant late RV mitochondrial and hemodynamic dysfunction at P365.”

   Animalsfollowing postnatal hyperoxia exposure

   Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart

   American journal of physiology. Heart and circulatory physiology·8 Nov 2019

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1. Hyperoxia impairs right ventricular function in rats.

   “at P21, hyperoxia-exposed rats demonstrated severe pulmonary hypertension and RV dysfunction”

   Animalspostnatal hyperoxia exposure14 days

   Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart

   American journal of physiology. Heart and circulatory physiology·8 Nov 2019

1. Hyperoxia decreases mitochondrial oxidative capacity in rats.

   “at P21, hyperoxia-exposed rats demonstrated severe pulmonary hypertension and RV dysfunction, accompanied by depressed mitochondrial oxidative capacity.”

   Animalspostnatal hyperoxia exposure14 days

   Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart

   American journal of physiology. Heart and circulatory physiology·8 Nov 2019

1. Hyperoxia has no effect on lipid peroxidation in mice.

   “No increase in LPO was observed after hyperoxia, regardless of sex.”

   Animalsbrain18-h

   Diminished Resistance to Hyperoxia in Brains of Reproductively Senescent Female CBA/H Mice

   Medical science monitor basic research·16 Sep 2015

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1. Hyperoxia increases SOD2 in mice.

   “SOD2 protein was upregulated only in females (p=0.008) while CAT (p=0.026) and HO-1 (p=0.042) proteins were increased after hyperoxia only in males.”

   Animalsbrain18-hfemales

   Diminished Resistance to Hyperoxia in Brains of Reproductively Senescent Female CBA/H Mice

   Medical science monitor basic research·16 Sep 2015

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