5 papers3 findings
MAPK11
downin mice1
MAPK11 protects against arrhythmias in mice (p = 0.0188).
“Arrhythmia inducibility studies revealed an increase in non-sustained arrhythmias in p38β -/- hearts (p = 0.0188).”
Animalsshown by knockoutheart
AHA Scientific Sessions 2025 abstract3 Nov 2025
Chronic kidney disease stage 3
upin humans1+70% all arrhythmia cases
Chronic kidney disease stage 3 is associated with arrhythmias in humans (70% of all arrhythmia cases).
“70% of all arrhythmia cases occurred in patients with CKD Stage 3.”
Humansin patients progressing from obesity to CKD
CKD and CKM Syndrome: Accelerated Progression to Arrhythmias in a National Cohort
AHA Scientific Sessions 2025 abstract3 Nov 2025
Chronic kidney disease
upin humans1
Chronic kidney disease is associated with arrhythmias in humans (4% (1,095/26,478) within a median of 4 months).
“progression from cardiometabolic dysfunction to CKD was associated with a marked rise in new arrhythmias, particularly AF.”
Humansin adults progressing from obesity to CKDn = 26,478
CKD and CKM Syndrome: Accelerated Progression to Arrhythmias in a National Cohort
AHA Scientific Sessions 2025 abstract3 Nov 2025
1 trialPhase 496 people
National Institute of Neurological Disorders and StrokeUS$947.9k
Across two validation cohorts of over 22,000 patients, an AI score from overnight heart traces yielded hazard ratios of 2.03 and 2.72 for atrial fibrillation.Across two validation cohorts of over 22,000 patients, an AI score from overnight heart traces yielded hazard ratios of 2.03 and 2.72 for atrial fibrillation.
After accounting for age, the rate rose from 0.65 deaths per 100,000 in 1999 to 1.32 in 2020 in US mortality records.After accounting for age, the rate rose from 0.65 deaths per 100,000 in 1999 to 1.32 in 2020 in US mortality records.
In 364 cardiac surgery patients, age (odds ratio 1.71 per decade) and a PITX2 variant (odds ratio 1.91) independently predicted postoperative atrial fibrillation, while…In 364 cardiac surgery patients, age (odds ratio 1.71 per decade) and a PITX2 variant (odds ratio 1.91) independently predicted postoperative atrial fibrillation, while inflammatory markers did not.