Homotaurine
Homotaurine has been studied in 3 papers since 2019: none in people yet, 1 in animals, 1 in cells, 1 review. The research so far is in animals and cells. The newest paper, Feb 21, 2025: “Antioxidant, Osteogenic, and Neuroprotective Effects of Homotaurine in Aging and Parkinson's Disease Models”.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: European Commission and 6 more
- Animals1
- Cells1
What did studies of homotaurine find?
8Studies of homotaurine measured 8 outcomes; the most studied are reactive oxygen species (1 study), angiogenesis (1) and osteogenesis (1).
Reactive oxygen species
downin cells1downin human cells1
1 study
Reactive oxygen species
downin cells1downin human cells1
Homotaurine decreases reactive oxygen species in LRRK2 G2019S midbrain organoids.
“homotaurine treatment enhanced β-catenin expression and reduced ROS levels”
Cellsin LRRK2 G2019S midbrain organoidsmidbrain organoids
Antioxidants (Basel, Switzerland)
Homotaurine decreases reactive oxygen species in cells.
“homotaurine treatment significantly reduced reactive oxygen species (ROS) levels”
Cellsmesenchymal stem cells
Antioxidants (Basel, Switzerland)
Angiogenesis
upin zebrafish1
1 study
Angiogenesis
upin zebrafish1
Homotaurine increases angiogenesis in aged zebrafish.
“increasing the levels of the kinase insert domain receptor-like angiogenesis marker in aged zebrafish”
Animalsin aged zebrafish
Antioxidants (Basel, Switzerland)
osteogenesis
upin zebrafish1
1 study
osteogenesis
upin zebrafish1
Homotaurine increases osteogenesis in zebrafish.
“homotaurine promoted osteogenesis and angiogenesis in zebrafish models”
Animals
Antioxidants (Basel, Switzerland)
Mesenchymal stem cell viability
upin cells1
1 study
Mesenchymal stem cell viability
upin cells1
Homotaurine improves mesenchymal stem cell viability in cells.
“improved MSC viability”
Cellsmesenchymal stem cells
Antioxidants (Basel, Switzerland)
GABAAR
upin mice1
1 study
GABAAR
upin mice1
Homotaurine activates GABAAR in murine cerebellar granule cells in brain slices (EC50 0.4 μM).
“HT is a very potent GABA mimetic, as it evokes GABAAR-mediated currents with an EC50 of 0.4 μM”
Animalsin murine cerebellar granule cells in brain slicescerebellum
GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions
Frontiers in pharmacology
Global cognitive decline
downin humans1
1 study
Global cognitive decline
downin humans1
Homotaurine decreases global cognitive decline in APOE ε4 allele carriers, post-hoc subgroup analysis.
“as well as a reduction in global cognitive decline in APOE ε4 allele carriers”
Reviewin APOE ε4 allele carriers, post-hoc subgroup analysis
Future strategies of management of Alzheimer's Disease. The role of homotaurine
Hellenic journal of nuclear medicine
Hippocampal volume loss
downin humans1
1 study
Hippocampal volume loss
downin humans1
Homotaurine decreases hippocampal volume loss in humans (post-hoc analyses of clinical trials in the overall cohort).
“post-hoc analyses have shown positive and significant effects on secondary endpoints and subgroups of patients, including a reduction in hippocampal volume loss”
Reviewpost-hoc analyses of clinical trials in the overall cohorthippocampus
Future strategies of management of Alzheimer's Disease. The role of homotaurine
Hellenic journal of nuclear medicine
Alzheimer's disease
downin reviews1
1 study
Alzheimer's disease
downin reviews1
Homotaurine protects against Alzheimer's disease.
“we will present the pre-clinical and clinical evidence supporting the potential role of homotaurine as a promising candidate for both primary and secondary prevention of AD”
Review
Future strategies of management of Alzheimer's Disease. The role of homotaurine
Hellenic journal of nuclear medicine
What is homotaurine linked with?
1Studies link homotaurine with 1 measure, most often GABAAR (1 study).
GABAAR
upin mice1
1 study
GABAAR
upin mice1
Homotaurine is associated with GABAAR in mice (displacement of [3H]muscimol binding in mouse brain homogenates) (IC50 0.16 μM for HT vs 125 μM for taurine).
“HT displaces the high affinity GABAAR ligand [3H]muscimol at similarly low concentrations (HT IC50 of 0.16 μM vs. 125 μM for taurine)”
Animalsdisplacement of [3H]muscimol binding in mouse brain homogenatesbrain
GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions
Frontiers in pharmacology