Hippocampal volume loss
2 papers3 findings
- Humans2
Interventions
1Physical activity
downin humans1
1 study
Physical activity
downin humans1
Physical activity decreases hippocampal volume loss in humans (p = 0.025).
“significant age × physical activity interactions for β-amyloid burden (p = 0.014), glucose metabolism (p = 0.015), and hippocampal volume (p = 0.025)”
Humanswith advancing agebrain
Physical activity attenuates age-related biomarker alterations in preclinical AD
Neurology8 Oct 2014
Upstream
1APOE
upin humans1
1 study
APOE
upin humans1
APOE increases hippocampal volume loss in humans.
“presence of APOE-ε4 was related to increased HVL bilaterally.”
Humanshippocampus4.5-yearn = 81
Neuro-degenerative diseases17 Dec 2019
Associations
1Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Hippocampal volume loss is associated with cognitive function in humans.
“There was a negative association between the CCS and HVL bilaterally.”
Humansbrain4.5-yearn = 81
Neuro-degenerative diseases17 Dec 2019
Latest
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Neuro-degenerative Diseases
Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects
Cohort study of 81 peopleMechanisms
NeuroImage Clinical
Hippocampal volume across age: Nomograms derived from over 19,700 people in UK Biobank
Cohort study of 19,793 peopleHippocampal volume
Neurology
Physical activity attenuates age-related biomarker alterations in preclinical AD
Cross-sectional study of 317 peoplePopulations
PNAS
Exercise training increases size of hippocampus and improves memory
Randomised trial in 120 peopleExercise