There is 1 paper on GABAAR in aging research: none in people yet, 1 in cells.
1 paper studies it3 findings
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Institute of Neurological Disorders and Stroke and 1 more
- Cells1
Interventions
2Taurine
upin mice1
1 study
Taurine
upin mice1
Taurine activates GABAAR in murine cerebellar granule cells in brain slices, compared with HT (EC50 116 μM for taurine vs 0.4 μM for HT).
“with both taurine and HT having similar efficacy in activating native GABAARs”
Animalsin murine cerebellar granule cells in brain slices, compared with HTcerebellum
GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions
Frontiers in pharmacology
Homotaurine
upin mice1
1 study
Homotaurine
upin mice1
Homotaurine activates GABAAR in murine cerebellar granule cells in brain slices (EC50 0.4 μM).
“HT is a very potent GABA mimetic, as it evokes GABAAR-mediated currents with an EC50 of 0.4 μM”
Animalsin murine cerebellar granule cells in brain slicescerebellum
GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions
Frontiers in pharmacology
Associations
1Homotaurine
upin mice1
1 study
Homotaurine
upin mice1
Homotaurine is associated with GABAAR in mice (displacement of [3H]muscimol binding in mouse brain homogenates) (IC50 0.16 μM for HT vs 125 μM for taurine).
“HT displaces the high affinity GABAAR ligand [3H]muscimol at similarly low concentrations (HT IC50 of 0.16 μM vs. 125 μM for taurine)”
Animalsdisplacement of [3H]muscimol binding in mouse brain homogenatesbrain
GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions
Frontiers in pharmacology