High-fructose corn syrup

2 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Ceramide

upin reviews1

1 study

High-fructose corn syrup increases ceramide.
“High-fructose corn syrup and saturated fatty acids promote Cer accumulation and IR”
Review
Modulation of ceramides through nutrition: A new target in obesity and insulin resistance (Narrative Review)
Clinical nutrition ESPEN2 Dec 2025

More on Ceramide

Brain volume

no changein rats1

1 study

High-fructose corn syrup has no effect on brain volume in rats.
“No significant differences were observed in hippocampal or total brain volumes between groups (p > 0.05).”
Animals11% weight/volume solution16 weeksmales
Cognitive and neuroanatomical effects of chronic high-fructose corn syrup consumption in the aging rat brain
BMC neuroscience28 Nov 2025

Locomotor activity

no changein rats1

1 study

High-fructose corn syrup has no effect on locomotor activity in rats.
“No significant differences were found among groups in locomotor activity or Y-maze performance (p > 0.05).”
Animals11% weight/volume solution16 weeksmales
Cognitive and neuroanatomical effects of chronic high-fructose corn syrup consumption in the aging rat brain
BMC neuroscience28 Nov 2025

Short-term working memory

no changein rats1

1 study

High-fructose corn syrup has no effect on short-term working memory in rats.
“No significant differences were found among groups in locomotor activity or Y-maze performance (p > 0.05).”
Animals11% weight/volume solution16 weeksmales
Cognitive and neuroanatomical effects of chronic high-fructose corn syrup consumption in the aging rat brain
BMC neuroscience28 Nov 2025

Body weight

upin rats1

1 study

High-fructose corn syrup increases body weight in rats.
“Per+HFCS rats consumed more HFCS and gained more weight than the other groups (p < 0.05).”
Animalswith 10 g chow/day11% weight/volume solution16 weeksmales
Cognitive and neuroanatomical effects of chronic high-fructose corn syrup consumption in the aging rat brain
BMC neuroscience28 Nov 2025