Glutamate

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country
0 on aging of 5 trials, 2 with no results posted

Funder: National Institute on Aging

Model organisms1
Cells1

Outcomes

Paracellular barrier function

upin mouse cells1

1 study

Glutamate improves paracellular barrier function in mouse cells.
“Glu reversed the Ten-1-induced reduction of CLDN10b mRNA and restored paracellular barrier function.”
Cellsin tenovin-1-treated MCE301 cells
Rescue of Aging-Dependent Reduction of Claudin-10b Expression by Glutamate in Mouse Intestinal MCE301 Cells
Journal of cellular biochemistry1 Nov 2025

CLDN10

upin mouse cells1

1 study

Glutamate increases CLDN10 in mouse cells.
“In mouse intestine-derived MCE301 cells, Glu treatment increased the mRNA levels of CLDN10b”
Cellsintestine
Rescue of Aging-Dependent Reduction of Claudin-10b Expression by Glutamate in Mouse Intestinal MCE301 Cells
Journal of cellular biochemistry1 Nov 2025

Trials

0 on aging of 5

In trials

Atherosclerosis
No phaseStatus unknown1 trial
Burning mouth syndrome
No phaseStatus unknown1 trial
Multiple sclerosis
No phaseCompleted1 trial
Pain
No phaseStatus unknown1 trial
Temporomandibular joint disorders
No phaseStatus unknown1 trial

Trial sponsors

Rambam Health Care Campus
1 trial110 people
Aalborg University
1 trial90 people
University Hospital, Caen
1 trial36 people
Wageningen University
1 trial12 people

Funding

2 grants since 2022

National Institute on AgingUS$4.5m

Latest

67 in 12 months

Circulation Reports9 Oct

Circulating Amino Acids Independently Predict Longitudinal Progression of Cardio–Ankle Vascular Index in Japanese Older Adults ― The Kyotango Longevity Cohort Study ―

Cohort study of 592 peopleCardio-ankle vascular index

Paper

bioRxiv2 Oct

Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice

Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.

Preprint: experiments in miceInflammation

Paper

bioRxiv2 Oct

Depletion of the isocitrate dehydrogenase 3 subunit IDHA-1 licenses germ cell-to-neuron direct reprogramming

Preprint: experiments in wormsEpigenetic regulation of gene expression

Paper

BMJ Open30 Sep

Natural history study of type 1 diabetes risk in adults (T1DRA): protocol for screening and follow-up of UK adults

Study protocolType 1 diabetes

Paper

Brain Communications28 Sep

Brain connectivity linked to inhibition balance shifts with age

Left parietal-putamen connectivity predicted better cognitive flexibility in young adults (r = 0.41) but worse performance in older adults (r = -0.33).Left parietal-putamen connectivity predicted better cognitive flexibility in young adults (r = 0.41) but worse performance in older adults (r = -0.33).

Cross-sectional study in peopleMechanisms

Paper

bioRxiv21 Sep