Ginsenoside rd

1. Ginsenoside rd inhibits renin–angiotensin system in mice.

   “GRd disrupted angiotensin II (Ang II)-mediated signaling by acting as a competitive antagonist at the Ang II type 1 receptor (AT1R)”

   Animalskidney

   Ginsenoside Rd attenuates renal aging and fibrosis through inhibition of angiotensin II type 1 receptor signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·Jun 10, 2026

More on Renin–angiotensin system

1. Ginsenoside rd improves renal function in mice.

   “GRd-treated kidneys ultimately exhibited significantly reduced fibrosis and improved functional outcomes.”

   Animalsin aged mice and multiple kidney injury modelskidney

   Ginsenoside Rd attenuates renal aging and fibrosis through inhibition of angiotensin II type 1 receptor signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·Jun 10, 2026

1. Ginsenoside rd decreases fibrosis in mice.

   “GRd-treated kidneys ultimately exhibited significantly reduced fibrosis and improved functional outcomes.”

   Animalsin aged mice and multiple kidney injury modelskidney

   Ginsenoside Rd attenuates renal aging and fibrosis through inhibition of angiotensin II type 1 receptor signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·Jun 10, 2026

More on Fibrosis

1. Ginsenoside rd decreases senescent cells in mice.

   “GRd administration attenuated renal damage, reduced senescent cell burden, and suppressed fibrotic remodeling in aged mice and in multiple kidney injury models.”

   Animalsin aged mice and multiple kidney injury modelskidney

   Ginsenoside Rd attenuates renal aging and fibrosis through inhibition of angiotensin II type 1 receptor signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·Jun 10, 2026

More on Senescent cells

1. Ginsenoside rd decreases kidney damage in mice.

   “GRd administration attenuated renal damage, reduced senescent cell burden, and suppressed fibrotic remodeling in aged mice and in multiple kidney injury models.”

   Animalsin aged mice and multiple kidney injury modelskidney

   Ginsenoside Rd attenuates renal aging and fibrosis through inhibition of angiotensin II type 1 receptor signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·Jun 10, 2026

1. Ginsenoside rd protects against Aβ-induced toxicity in worms.

   “GS-Rd significantly reduces Aβ aggregation”

   Model organismsin transgenic C. elegans expressing Aβ

   Ginsenoside Rd protects transgenic Caenorhabditis elegans from β-amyloid toxicity by activating oxidative resistant

   Frontiers in pharmacology·Dec 15, 2022

1. Ginsenoside rd decreases reactive oxygen species in worms.

   “GS-Rd decreased reactive oxygen species (ROS) levels”

   Model organismsin CL4176 worms

   Ginsenoside Rd protects transgenic Caenorhabditis elegans from β-amyloid toxicity by activating oxidative resistant

   Frontiers in pharmacology·Dec 15, 2022

More on Reactive oxygen species

1. Ginsenoside rd decreases paralysis in worms.

   “delays physical paralysis”

   Model organismsin CL4176 worms expressing Aβ

   Ginsenoside Rd protects transgenic Caenorhabditis elegans from β-amyloid toxicity by activating oxidative resistant

   Frontiers in pharmacology·Dec 15, 2022

1. Ginsenoside rd improves heat resistance in worms.

   “improves resistance to heat stress”

   Model organismsunder heat stress

   Ginsenoside Rd protects transgenic Caenorhabditis elegans from β-amyloid toxicity by activating oxidative resistant

   Frontiers in pharmacology·Dec 15, 2022

1. Ginsenoside rd extends lifespan in worms.

   “GS-Rd prolongs lifespan”

   Model organismsin transgenic Caenorhabditis elegans model of Alzheimer's disease

   Ginsenoside Rd protects transgenic Caenorhabditis elegans from β-amyloid toxicity by activating oxidative resistant

   Frontiers in pharmacology·Dec 15, 2022