Gamma-oryzanol

Intervention

1 paper5 findings

PubChemChEBI

  • 1 lab in 1 country
  • Funder: Mokpo National University
  • Cells1

Outcomes

5

NOS3

upin pig cells1

1 study
  1. Gamma-oryzanol increases NOS3 in pig cells.

    “γ-Orz suppressed sodium-glucose co-transporter 2 expression, reduced NADPH oxidase overexpression, and restored eNOS levels”

    Cellsin replicative senescent endothelial cells

    γ-Oryzanol Ameliorates Endothelial Replicative Senescence via Downregulation of SGLT2 Expression to Attenuate NADPH-Driven Oxidative Stress

    Biomolecules & therapeutics27 Feb 2026

More on NOS3

SLC5A2

downin pig cells1

1 study
  1. Gamma-oryzanol decreases SLC5A2 in pig cells.

    “γ-Orz suppressed sodium-glucose co-transporter 2 expression, reduced NADPH oxidase overexpression, and restored eNOS levels”

    Cellsin replicative senescent endothelial cells

    γ-Oryzanol Ameliorates Endothelial Replicative Senescence via Downregulation of SGLT2 Expression to Attenuate NADPH-Driven Oxidative Stress

    Biomolecules & therapeutics27 Feb 2026

More on SLC5A2

Oxidative stress and ROS signalling

downin pig cells1

1 study
  1. Gamma-oryzanol decreases oxidative stress and ROS signalling in pig cells.

    “RBE and γ-Orz significantly reduced SA-β-gal activity, improved proliferation, and decreased oxidative stress in P3 cells”

    Cellsin P3 replicative senescent endothelial cells

    γ-Oryzanol Ameliorates Endothelial Replicative Senescence via Downregulation of SGLT2 Expression to Attenuate NADPH-Driven Oxidative Stress

    Biomolecules & therapeutics27 Feb 2026

More on Oxidative stress and ROS signalling

Cell proliferation

upin pig cells1

1 study
  1. Gamma-oryzanol improves cell proliferation in pig cells.

    “RBE and γ-Orz significantly reduced SA-β-gal activity, improved proliferation, and decreased oxidative stress in P3 cells”

    Cellsin P3 replicative senescent endothelial cells

    γ-Oryzanol Ameliorates Endothelial Replicative Senescence via Downregulation of SGLT2 Expression to Attenuate NADPH-Driven Oxidative Stress

    Biomolecules & therapeutics27 Feb 2026

Senescence-associated beta-galactosidase

downin pig cells1

1 study
  1. Gamma-oryzanol decreases senescence-associated beta-galactosidase in pig cells.

    “RBE and γ-Orz significantly reduced SA-β-gal activity, improved proliferation, and decreased oxidative stress in P3 cells”

    Cellsin P3 replicative senescent endothelial cells

    γ-Oryzanol Ameliorates Endothelial Replicative Senescence via Downregulation of SGLT2 Expression to Attenuate NADPH-Driven Oxidative Stress

    Biomolecules & therapeutics27 Feb 2026

More on Senescence-associated beta-galactosidase

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