Metformin + galantamine

1. Metformin + galantamine decreases myofiber damage in mice.

   “Denervation and myofiber damage were decreased in RJx-01-treated animals compared with controls.”

   Animals

   A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia

   JCI insight·8 Aug 2023

1. Metformin + galantamine decreases inflammation in mice.

   “In these mice, RJx-01 ameliorated physical performance, muscle mass and force, neuromuscular junction stability, and systemic inflammation.”

   Animalsin Opa1-/- transgenic mice

   A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia

   JCI insight·8 Aug 2023

More on Inflammation

1. Metformin + galantamine improves physical function in mice.

   “In these mice, RJx-01 ameliorated physical performance, muscle mass and force, neuromuscular junction stability, and systemic inflammation.”

   Animalsin Opa1-/- transgenic mice

   A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia

   JCI insight·8 Aug 2023

1. Metformin + galantamine extends lifespan in worms.

   “In worms, RJx-01 treatment improved lifespan, locomotion, pharyngeal pumping, and muscle fiber organization.”

   Model organisms

   A combination of metformin and galantamine exhibits synergistic benefits in the treatment of sarcopenia

   JCI insight·8 Aug 2023