Flavonoids and their metabolites

1. Flavonoids and their metabolites increase LDLR expression.

   “suppression of SREBP-1c, enhancement of LDL receptor expression”

   Reviewmanagement of hyperlipidaemia

   Therapeutic Potential of Flavonoids and Their Metabolites in Hyperlipidaemia: Molecular Mechanisms, Bioavailability and Clinical Perspectives

   Current pharmaceutical design·9 Oct 2026

More on LDLR expression

1. Flavonoids and their metabolites activate AMPK signalling.

   “including the inhibition of HMG-CoA reductase, activation of AMPK and PPARα”

   Reviewmanagement of hyperlipidaemia

   Therapeutic Potential of Flavonoids and Their Metabolites in Hyperlipidaemia: Molecular Mechanisms, Bioavailability and Clinical Perspectives

   Current pharmaceutical design·9 Oct 2026

More on AMPK signalling

1. Flavonoids and their metabolites inhibit HMGCR.

   “Evidence indicates that flavonoids and their metabolites modulate multiple pathways involved in lipid homeostasis, including the inhibition of HMG-CoA reductase”

   Reviewmanagement of hyperlipidaemia

   Therapeutic Potential of Flavonoids and Their Metabolites in Hyperlipidaemia: Molecular Mechanisms, Bioavailability and Clinical Perspectives

   Current pharmaceutical design·9 Oct 2026

More on HMGCR