Ergothioneine

1. Ergothioneine increases SLC22A4 in mouse cells.

   Cellsin bone-derived type H endothelial cells

   Ergothioneine Attenuates Ovariectomy-Induced Bone Loss in Association With Reduced Oxidative Stress and Enhanced Type H Vessel-Related Angiogenesis · Frontiers in bioscience (Landmark edition) · 1 Sep 2026

SLC22A4 →

1. Ergothioneine increases angiogenesis in mice.

   Animalsin ovariectomized micebone12 weeksfemales

   Ergothioneine Attenuates Ovariectomy-Induced Bone Loss in Association With Reduced Oxidative Stress and Enhanced Type H Vessel-Related Angiogenesis · Frontiers in bioscience (Landmark edition) · 1 Sep 2026

Angiogenesis →

1. Ergothioneine decreases oxidative stress and ROS signalling in mice.

   Animalsin ovariectomized miceserum12 weeksfemales

   Ergothioneine Attenuates Ovariectomy-Induced Bone Loss in Association With Reduced Oxidative Stress and Enhanced Type H Vessel-Related Angiogenesis · Frontiers in bioscience (Landmark edition) · 1 Sep 2026

Oxidative stress and ROS signalling →

1. Ergothioneine increases bone mineral density in mice.

   Animalsin ovariectomized micefemur12 weeksfemales

   Ergothioneine Attenuates Ovariectomy-Induced Bone Loss in Association With Reduced Oxidative Stress and Enhanced Type H Vessel-Related Angiogenesis · Frontiers in bioscience (Landmark edition) · 1 Sep 2026