Environmental stress
Environmental stress has been studied in 11 papers since 2015: none in people yet, 4 in animals, 1 in cells, 6 reviews; 1 in the past year. The research so far is in animals and cells. The newest paper, Apr 2, 2026: “ER discontinuities are common in C. elegans neurons, revealing a genetically tractable model for ER network maintenance”.
11 papers study it8 findingsUpdated
None of its findings points the other way.
- 3 independent labs in 3 countries
- Funders: National Institutes of Health and others
- Animals2
- Model organisms2
- Cells1
What did studies of Environmental stress find?
6Studies of Environmental stress measured 6 outcomes; the most studied are ER discontinuities (1 study), H19 (1) and breeding performance (1).
ER discontinuities
upin worms1
1 study
ER discontinuities
upin worms1
Environmental stress increases ER discontinuities in worms.
“Suggesting the formation of discontinuities is linked to cellular damage, their frequency increases with both age and environmental stress.”
Model organismsneurite
bioRxiv : the preprint server for biologyPreprint
H19
upin reviews1
1 study
H19
upin reviews1
Environmental stress induces H19.
“We propose that H19 is a stress-induced long non-coding RNA.”
Review
The Roles of H19 in Regulating Inflammation and Aging
Frontiers in immunology
Breeding performance
downin T. guttata1
1 study
Breeding performance
downin T. guttata1
Environmental stress impairs breeding performance in T. guttata (Mildly challenging environmental circumstances).
“reduced breeding performance during early adulthood, but had positive effects when individuals were bred in old adulthood.”
AnimalsMildly challenging environmental circumstances
Environmental conditions shape the temporal pattern of investment in reproduction and survival
Proceedings. Biological sciences
Cellular senescence
upin E. coli1
1 study
Cellular senescence
upin E. coli1
Environmental stress induces cellular senescence in E. coli under environmental stress.
“They indicate that E. coli and S. pombe do age, but only when subjected to environmental stress.”
Reviewunder environmental stress
Aging and immortality in unicellular species
Mechanisms of ageing and development
Proteostasis
downin worms1
1 study
Proteostasis
downin worms1
Environmental stress protects against proteostasis in worms.
“Animals subjected to various stressors during developmental stages exhibit increased resistance to oxidative stress and proteotoxicity.”
Model organisms
Nature communications
Oxidative stress and ROS signaling
downin worms1
1 study
Oxidative stress and ROS signaling
downin worms1
Environmental stress protects against oxidative stress and ROS signaling in worms.
“Animals subjected to various stressors during developmental stages exhibit increased resistance to oxidative stress and proteotoxicity.”
Model organisms
Nature communications
What is Environmental stress linked with?
2Studies link Environmental stress with 2 measures, most often retrotransposable element reactivation (1 study) and age-dependent immunity (1).
retrotransposable element reactivation
upin reviews1
1 study
retrotransposable element reactivation
upin reviews1
Environmental stress is associated with retrotransposable element reactivation.
“Environmental stress is associated with both ageing-related characteristics and the epigenetic mechanisms that control RTE activity”
Review
Reactivation of retrotransposable elements is associated with environmental stress and ageing
Nature reviews. Genetics
Age-dependent immunity
mixedin flies1
1 study
Age-dependent immunity
mixedin flies1
Environmental stress is associated with age-dependent immunity in flies.
“we review the effects that factors such as sexual dimorphism, environmental stress, and cellular physiology exert on age-dependent immunity in Drosophila”
Review
The Impact of Age on Response to Infection in Drosophila
Microorganisms
Funding
3 grants since 2023National Heart, Lung, and Blood Institute$2.2MAgence Nationale de la Recherche€522KNatural Sciences and Engineering Research CouncilCA$37K
Maternal mRNA epitranscriptomics in oocyte adaptation to environmental stress
Agence Nationale de la RechercheInstitut de Biologie Valrose€522K2025
Natural Sciences and Engineering Research CouncilUniversity of SaskatchewanCA$37K2023–2024
National Heart, Lung, and Blood InstituteNational Heart, Lung, and Blood Institute$869K