Environmental pollutants

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans1

Outcomes

3

Cellular senescence

upin reviews1

1 study

Environmental pollutants induce cellular senescence.
“This promotes the pathological accumulation of senescent T cells and Age-associated B Cells (ABCs)”
Reviewchronic environmental exposure
The exposome-autoimmunity axis: environmental xenobiotics, gut dysbiosis, and potential pathways to immunosenescence
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association10 Aug 2026

More on Cellular senescence

Telomerase and telomere maintenance

downin reviews1

1 study

Environmental pollutants impair telomerase and telomere maintenance.
“Chronic environmental exposure accelerates telomere attrition, inducing premature immunosenescence and inflammaging.”
Reviewchronic environmental exposure
The exposome-autoimmunity axis: environmental xenobiotics, gut dysbiosis, and potential pathways to immunosenescence
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association10 Aug 2026

More on Telomerase and telomere maintenance

Predictive performance

no changein humans1

1 study

Environmental pollutants have no effect on predictive performance in humans.
“Including chemical exposure data did not statistically improve model performance compared to baseline models with only demographic and clinical covariates.”
Humans
Environmental chemical factors associated with human biological age acceleration: an interpretable machine learning study
Archives of gerontology and geriatrics21 Oct 2025

Latest

2 in 12 months

Food and Chemical Toxicology11 Aug

The exposome-autoimmunity axis: environmental xenobiotics, gut dysbiosis, and potential pathways to immunosenescence

ReviewMicrobiome composition

Apoptosis3 Mar

cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication

ReviewFerroptosis

Archives of Gerontology and Geriatrics25 Oct

Environmental chemical factors associated with human biological age acceleration: an interpretable machine learning study

Cross-sectional study of 1,693 peoplePopulations