Age-associated B cells

Biomarker2 papers2 findings

Animals1

Interventions

1

Rapamycin

downin mice1Very low certainty

1 study

Rapamycin decreases age-associated B cells in mice.
Animalsestablished atherosclerotic lesionsintraperitonealspleen and lymph nodestriweekly8 weeksmales
Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice · Aging cell · 23 Sep 2026

Upstream

1

Autoimmune disease

upin reviews1

1 study

Autoimmune disease increases age-associated B cells.
Review
The Developmental and Functional Implications of Age-Associated B Cells (ABCs) Across Tissue Microenvironments · Immunological reviews · 1 Aug 2026

Autoimmune disease →

Funding

National Institute of Allergy and Infectious DiseasesUS$586.1k1 grant since 2024

How Distinct Age-Associated B Cell Subsets Can Protect the Aged from Influenza
National Institute of Allergy and Infectious DiseasesUniv of Massachusetts Med Sch WorcesterUS$586.1k2024–2029

Latest

6

Aging CellAnimals23 Sep

Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice

GeroScienceReview22 Sep

A two-step model of age-associated autoreactivity: B cell-intrinsic aging meets inflammaging

Progress in NeurobiologyReview16 Sep

The dimorphic brain in ischemic stroke: How sex and age shape molecular pathophysiology and therapeutic responsiveness

Research SquareAnimalsPreprint4 Sep

Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses

Blood and immune system

Journal of AutoimmunityIn silico28 Aug

Multimodal computational framework resolves B cell maturation in autoimmunity and ageing

Blood and immune system

Immunological ReviewsReview25 Aug

The Developmental and Functional Implications of Age-Associated B Cells (ABCs) Across Tissue Microenvironments

Blood and immune system