Dimethyloxalylglycine

1. Dimethyloxalylglycine decreases oxidative stress and ROS signalling in human cells.

   “DMOG pretreatment restored osteogenic differentiation, suppressed adipogenesis, improved mitochondrial dynamics, reduced oxidative stress, and enhanced bioenergetic metabolism.”

   Cellsin necrotic femoral head BMSCs (fhBMSCs) from ONFH patients

   DMOG pretreatment restores osteogenic-adipogenic balance and mitochondrial function in ONFH BMSCs through the HIF-1α/Homer3 pathway

   Stem cell research & therapy·Apr 19, 2026

More on Oxidative stress and ROS signalling

1. Dimethyloxalylglycine decreases adipogenesis in human cells.

   “DMOG pretreatment restored osteogenic differentiation, suppressed adipogenesis, improved mitochondrial dynamics, reduced oxidative stress, and enhanced bioenergetic metabolism.”

   Cellsin necrotic femoral head BMSCs (fhBMSCs) from ONFH patients

   DMOG pretreatment restores osteogenic-adipogenic balance and mitochondrial function in ONFH BMSCs through the HIF-1α/Homer3 pathway

   Stem cell research & therapy·Apr 19, 2026

1. Dimethyloxalylglycine increases osteogenic differentiation in human cells.

   “DMOG pretreatment restored osteogenic differentiation, suppressed adipogenesis, improved mitochondrial dynamics, reduced oxidative stress, and enhanced bioenergetic metabolism.”

   Cellsin necrotic femoral head BMSCs (fhBMSCs) from ONFH patients

   DMOG pretreatment restores osteogenic-adipogenic balance and mitochondrial function in ONFH BMSCs through the HIF-1α/Homer3 pathway

   Stem cell research & therapy·Apr 19, 2026

1. Dimethyloxalylglycine increases mitophagy in human cells.

   “DMOG also promoted mitophagy, as evidenced by increased colocalization of mitochondria with lysosomes.”

   Cellsin senescent MSCsmesenchymal stem cells48 h

   Short-Term DMOG treatment rejuvenates senescent mesenchymal stem cells by enhancing mitochondrial function and mitophagy through the HIF-1α/BNIP3 pathway

   Stem cell research & therapy·Jun 2, 2025

More on Mitophagy

1. Dimethyloxalylglycine decreases cellular senescence in human cells.

   “DMOG treatment significantly reduced key senescence markers, including senescence-associated beta-galactosidase, p53, and p21, in both senescence models.”

   Cellsin MSC senescence modelsmesenchymal stem cells48 h

   Short-Term DMOG treatment rejuvenates senescent mesenchymal stem cells by enhancing mitochondrial function and mitophagy through the HIF-1α/BNIP3 pathway

   Stem cell research & therapy·Jun 2, 2025

More on Cellular senescence