Diallyl trisulfide

1. Diallyl trisulfide protects against cystitis in mice.

   “administration of diallyl trisulfide (DATS), an H2S donor, markedly ameliorated bladder pathology.”

   Animalsin cyclophosphamide-induced cystitisbladder

   Hydrogen sulfide and ferroptosis inhibition underlies the dietary restriction-induced protection against cyclophosphamide cystitis

   Frontiers in pharmacology·May 13, 2025

More on Cystitis

1. Diallyl trisulfide improves renal function in mice.

   “improved vascular density, blood flow, and renal function.”

   Animalsrenal IRIkidneyfemales

   Diallyl Trisulfide Attenuates Ischemia-Reperfusion-Induced ER Stress and Kidney Dysfunction in Aged Female Mice

   Cells·Mar 12, 2025

1. Diallyl trisulfide increases angiogenesis in mice.

   “DATS treatment upregulated PI3K, AKT, p-mTOR, and pMAPK signaling to stimulate angiogenesis”

   Animalsrenal IRIkidneyfemales

   Diallyl Trisulfide Attenuates Ischemia-Reperfusion-Induced ER Stress and Kidney Dysfunction in Aged Female Mice

   Cells·Mar 12, 2025

More on Angiogenesis

1. Diallyl trisulfide decreases fibrosis markers in mice.

   “and reduced inflammation and fibrosis markers in the IRI kidney.”

   Animalsrenal IRIkidneyfemales

   Diallyl Trisulfide Attenuates Ischemia-Reperfusion-Induced ER Stress and Kidney Dysfunction in Aged Female Mice

   Cells·Mar 12, 2025

More on Fibrosis markers

1. Diallyl trisulfide decreases inflammation in mice.

   “reduced inflammation and fibrosis markers in the IRI kidney.”

   Animalsrenal IRIkidneyfemales

   Diallyl Trisulfide Attenuates Ischemia-Reperfusion-Induced ER Stress and Kidney Dysfunction in Aged Female Mice

   Cells·Mar 12, 2025

More on Inflammation

1. Diallyl trisulfide decreases ER unfolded protein response in mice.

   “DATS mitigated ER stress, and reduced inflammation and fibrosis markers in the IRI kidney.”

   Animalsrenal IRIkidneyfemales

   Diallyl Trisulfide Attenuates Ischemia-Reperfusion-Induced ER Stress and Kidney Dysfunction in Aged Female Mice

   Cells·Mar 12, 2025

More on ER unfolded protein response

1. Diallyl trisulfide increases RUNX2 in mice.

   “Furthermore, Runx2 and β-catenin gene expression levels increased in bones, which may be related to the ameliorative mechanism of DATS.”

   Animalsin natural aging micebone

   Diallyl trisulfide ameliorates bone loss and alters specific gut microbiota and serum metabolites in natural aging mice

   Food & function·Aug 4, 2023

More on RUNX2

1. Diallyl trisulfide decreases sphingosine in mice.

   “Additionally, there has been a significant reduction in sphingosine, which is directly associated with bone metabolism.”

   Animalsin natural aging mice

   Diallyl trisulfide ameliorates bone loss and alters specific gut microbiota and serum metabolites in natural aging mice

   Food & function·Aug 4, 2023

More on Sphingosine

1. Diallyl trisulfide protects against bone loss in mice.

   “DATS treatment improved the bone microstructure, including the disorganized arrangement of bone trabeculae and promoted collagen synthesis”

   Animalsin natural aging mice

   Diallyl trisulfide ameliorates bone loss and alters specific gut microbiota and serum metabolites in natural aging mice

   Food & function·Aug 4, 2023