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Dasatinib + ellagic acid

Intervention

1 paper2 findings

PubChemPubChemChEBIChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 1 more
  • Cells1

Outcomes

2

BCL2

downin human cells1

1 study

  1. Dasatinib + ellagic acid decreases BCL2 in human cells.

    “Both drug combinations increased apoptosis, reduced BCL-2 expression, and increased caspase activity in senescent MRC-5 cells.”

    Cellsin senescent MRC-5 cells

    Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line

    Pharmaceuticals (Basel, Switzerland)4 Jan 2024

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Apoptosis

upin human cells1

1 study

  1. Dasatinib + ellagic acid induces apoptosis in human cells.

    “Both drug combinations increased apoptosis, reduced BCL-2 expression, and increased caspase activity in senescent MRC-5 cells.”

    Cellsin senescent MRC-5 cells

    Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line

    Pharmaceuticals (Basel, Switzerland)4 Jan 2024

More on Apoptosis

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