Azithromycin

2 papers4 findings

PubChem ChEBI MeSH

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals1
Cells1

Outcomes

4

Cellular senescence

downin human cells1

1 study

Azithromycin decreases cellular senescence in human cells.
“Azithromycin preconditioning reduced p53, p21, and CCND1 expression and increased FOXO3A.”
Cellsin CSE-exposed BEAS-2B cells
Azithromycin Mitigates Tobacco Smoke-Induced Lung Senescence by Modulating the FOXO3A/CCND1 Signaling Pathway
International journal of chronic obstructive pulmonary disease11 Nov 2025

More on Cellular senescence

CCND1

downin mice1

1 study

Azithromycin decreases CCND1 in mice.
“Azithromycin treatment lowered SASP secretion and decreased CCND1, p53, and p21 expression, while increasing FOXO3A.”
Animalsin CS-exposed emphysema micelung
Azithromycin Mitigates Tobacco Smoke-Induced Lung Senescence by Modulating the FOXO3A/CCND1 Signaling Pathway
International journal of chronic obstructive pulmonary disease11 Nov 2025

FOXO3

upin mice1

1 study

Azithromycin increases FOXO3 in mice.
“Azithromycin treatment lowered SASP secretion and decreased CCND1, p53, and p21 expression, while increasing FOXO3A.”
Animalsin CS-exposed emphysema micelung
Azithromycin Mitigates Tobacco Smoke-Induced Lung Senescence by Modulating the FOXO3A/CCND1 Signaling Pathway
International journal of chronic obstructive pulmonary disease11 Nov 2025

Senescence-associated secretory phenotype (SASP)

downin mice1

1 study

Azithromycin decreases senescence-associated secretory phenotype (SASP) in mice.
“Azithromycin treatment lowered SASP secretion and decreased CCND1, p53, and p21 expression, while increasing FOXO3A.”
Animalsin CS-exposed emphysema micelung
Azithromycin Mitigates Tobacco Smoke-Induced Lung Senescence by Modulating the FOXO3A/CCND1 Signaling Pathway
International journal of chronic obstructive pulmonary disease11 Nov 2025

More on Senescence-associated secretory phenotype (SASP)

Latest

1 in 12 months

International Journal of Chronic Obstructive Pulmonary Disease17 Nov

Azithromycin Mitigates Tobacco Smoke-Induced Lung Senescence by Modulating the FOXO3A/CCND1 Signaling Pathway

Experiments in miceLung

Reproductive Biology and Endocrinology27 Mar

A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression

Experiments in animalsInterventions

Iranian Journal of Basic Medical Sciences10 Oct

Vitamin C, doxycycline, and azithromycin (VDA) targeted changes in cellular senescence-related genes in human adipose-derived mesenchymal stem cells

Experiments in cellsInterventions

Preprints.org25 Mar

Double Targeting Inflammasome Activation and Accelerated Cellular Senescence in Alveolar Macrophages Exposed to Cigarette Smoke and COPD

Preprint: study in peopleChronic obstructive pulmonary disease

Pharmaceuticals23 Jan

Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line

Experiments in human cellsSenolytics