Caffeic acid

1. Caffeic acid improves physical function in mice.

   “alleviating pulmonary pathology, and improving physical function in a bleomycin-induced pulmonary fibrosis mouse model.”

   Animalsin a bleomycin-induced pulmonary fibrosis mouse model

   Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

   Exploration (Beijing, China)·12 Dec 2025

1. Caffeic acid decreases pulmonary fibrosis in mice.

   “CA exhibited a promising effect in limiting inflammation in the lung and circulatory system, alleviating pulmonary pathology, and improving physical function in a bleomycin-induced pulmonary fibrosis mouse model.”

   Animalsin a bleomycin-induced pulmonary fibrosis mouse modellung

   Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

   Exploration (Beijing, China)·12 Dec 2025

More on Pulmonary fibrosis

1. Caffeic acid decreases ANXA5 in mouse cells.

   “covalent binding of CA to Annexin A5 protein triggered its degradation, PKCθ deactivation, and the inhibition of the NF-κB inflammatory pathway in senescent cells.”

   Cellsin senescent cells

   Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

   Exploration (Beijing, China)·12 Dec 2025

More on ANXA5

1. Caffeic acid inhibits senescence-associated secretory phenotype (SASP) in mouse cells.

   “caffeic acid (CA), to act as a potent senomorphic that effectively inhibits the secretion of SASP in senescent lung cells.”

   Cellsin senescent lung cells

   Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

   Exploration (Beijing, China)·12 Dec 2025

More on Senescence-associated secretory phenotype (SASP)