D-serine

2 papers3 findings

2 independent labs in 2 countries

Funders: Centre National de la Recherche Scientifique and 5 more

Animals2

Outcomes

3

Cognitive decline

downin mice1

1 study

D-serine decreases cognitive decline in mice.
“D-serine supplement rescued cognitive decline in aged mice”
Animals
Hypothalamic Menin regulates systemic aging and cognitive decline
PLoS biology16 Mar 2023

More on Cognitive decline

Adult-born DG cells

upin mice1

1 study

D-serine increases adult-born DG cells in mice.
“induced a modest increase in the number of 4-week-old adult-born cells in the DG”
Animalsdentate gyrus
Age-related vulnerability of pattern separation in C57BL/6J mice
Neurobiology of aging25 Oct 2017

More on Adult-born DG cells

Pattern separation

upin mice1

1 study

D-serine improves pattern separation in mice.
“Subchronic treatment with the cognitive enhancer D-serine fully rescued spatial PS performance in 18-month-old mice”
Animals
Age-related vulnerability of pattern separation in C57BL/6J mice
Neurobiology of aging25 Oct 2017

Latest

3 in 12 months

Journal of Alzheimer's Disease16 Sep

L-serine-enriched diet restores impaired adult neurogenesis in the hippocampus of 3xTg-AD mice

Experiments in miceInterventions

Ageing Research Reviews17 May

A novel mechanism of exercise-induced cognitive protection in ageing: D-amino acid oxidase /D-serine-dependent modulation of NMDAR signalling

Cell Metabolism5 Apr

Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia

Experiments in animalsInterventions

Investigative Ophthalmology & Visual Science15 Jan

Age- and Sex-Specific Regulation of Serine Racemase in the Retina of an Alzheimer's Disease Mouse

Experiments in animalsMechanisms

GSA 2024 Abstract1 Jan

MICROBIOME-KIDNEY METABOLISM PROVIDES INSIGHT INTO THE MECHANISM OF ICARIIN ALLEVIATES AGING IN OLDER FEMALE MICE

Experiments in miceGut and microbiome

Frontiers in Pharmacology26 Sep

Triiodothyronine acts on DAO to regulate pulmonary fibrosis progression by facilitating cell senescence through the p53/p21 signaling pathway

Experiments in animalsMechanisms

Chemical Record25 Sep

Physiology, Pathophysiology and Clinical Relevance of D-Amino Acids Dynamics: From Neurochemistry to Pharmacotherapy

ReviewMechanisms

Aging18 May

Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats

Experiments in ratsMechanisms

PLOS Biology16 Mar

Hypothalamic Menin regulates systemic aging and cognitive decline

Experiments in miceCognitive decline

Neurobiology of Aging25 Oct

Age-related vulnerability of pattern separation in C57BL/6J mice

Experiments in miceInterventions