Cynaroside

1. Cynaroside inhibits cellular senescence in mice.

   “(3) suppressing hepatocyte senescence and the secretion of SASP factors.”

   AnimalsNASH-T2DM micehepatocyteweek 5 to week 8males

   Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM

   Biomolecules·18 Aug 2025

More on Cellular senescence

1. Cynaroside decreases intrahepatic lipid accumulation in mice.

   “(2) decreasing intrahepatic lipid accumulation;”

   AnimalsNASH-T2DM miceliverweek 5 to week 8males

   Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM

   Biomolecules·18 Aug 2025

1. Cynaroside decreases hepatocellular injury in mice.

   “Cynaroside administration ameliorated hepatic pathology in NASH-T2DM mice by (1) reducing hepatocellular injury and lobular inflammation;”

   AnimalsNASH-T2DM miceliverweek 5 to week 8males

   Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM

   Biomolecules·18 Aug 2025

1. Cynaroside protects against polyglutamine diseases in worms.

   “Cynaroside also improved neurodegeneration diseases such as Alzheimer's and polyglutamine disease by suppressing insulin/IGF-1 signaling pathway.”

   Model organisms

   Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans

   Archives of gerontology and geriatrics·20 Feb 2024

More on Polyglutamine diseases

1. Cynaroside protects against Alzheimer's disease in worms.

   “Cynaroside also improved neurodegeneration diseases such as Alzheimer's and polyglutamine disease by suppressing insulin/IGF-1 signaling pathway.”

   Model organisms

   Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans

   Archives of gerontology and geriatrics·20 Feb 2024

More on Alzheimer's disease

1. Cynaroside activates daf-16 in worms.

   “followed by the activation of transcription factor DAF-16/FOXO to extend the healthy lifespan.”

   Model organismsshown via genetic screen

   Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans

   Archives of gerontology and geriatrics·20 Feb 2024

More on daf-16

1. Cynaroside inhibits daf-2 in worms.

   “Cynaroside acted on IGF-1-R /DAF-2, which was followed by the activation of transcription factor DAF-16/FOXO to extend the healthy lifespan.”

   Model organismsshown via genetic screen

   Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans

   Archives of gerontology and geriatrics·20 Feb 2024

More on daf-2

1. Cynaroside extends lifespan in worms.

   “10 μM Cynaroside significantly promoted the healthy lifespan in wild-type animals.”

   Model organisms10 μM

   Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans

   Archives of gerontology and geriatrics·20 Feb 2024