Cold temperature

1. Cold temperature has no effect on longevity in A. arabiensis.

   “Cold selection significantly increased adult female longevity at 18°C in SENN-DDT but not SENN.”

   Model organismsat 18°C in SENN strainfemales

   The effect of artificial cold selection on the behaviour and immune response of the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

   Acta tropica·3 Jul 2025

2. Cold temperature extends lifespan longevity in A. arabiensis.

   “Cold selection significantly increased adult female longevity at 18°C in SENN-DDT but not SENN.”

   Model organismsat 18°C in insecticide-resistant SENN-DDT strainfemales

   The effect of artificial cold selection on the behaviour and immune response of the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

   Acta tropica·3 Jul 2025

1. Cold temperature decreases SIRT3 in G. aculeatus.

   “SIRT3 protein levels declined”

   Animalscold acclimation

   Sirtuins may mediate temperature-induced metabolic remodeling in threespine stickleback

   Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·1 Dec 2025

More on SIRT3

1. Cold temperature activates sirtuin signalling in G. aculeatus.

   “Sirtuin activity significantly increased in response to cold acclimation in liver and oxidative and glycolytic muscles”

   Animalscold acclimation (5 °C vs 12 and 20 °C)liver and oxidative and glycolytic muscles

   Sirtuins may mediate temperature-induced metabolic remodeling in threespine stickleback

   Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·1 Dec 2025

More on Sirtuin signalling

1. Cold temperature activates immune response in A. arabiensis.

   “Cold treatment increased Attacin and cecropin expression in both strains but had no effect on Defensin and Gambicin expression.”

   Model organismsin both strains

   The effect of artificial cold selection on the behaviour and immune response of the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

   Acta tropica·3 Jul 2025

More on Immune response

1. Cold temperature impairs biting success in A. arabiensis.

   “However, it decreased biting success at 20°C in both strains.”

   Model organismsat 20°C in both strains

   The effect of artificial cold selection on the behaviour and immune response of the major malaria vector Anopheles arabiensis (Diptera: Culicidae)

   Acta tropica·3 Jul 2025

1. Cold temperature decreases neurodegeneration in human cells.

   “exposure of human cells to moderate cold temperature (36 °C) also activates trypsin-like activity through PA28γ/PSME3, reducing disease-related protein aggregation and neurodegeneration.”

   Cellsthrough PSME3human cells36 °C

   Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

   Nature aging·3 Apr 2023

1. Cold temperature decreases disease-related protein aggregation in human cells.

   “exposure of human cells to moderate cold temperature (36 °C) also activates trypsin-like activity through PA28γ/PSME3, reducing disease-related protein aggregation and neurodegeneration.”

   Cellsthrough PSME3human cells36 °C

   Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

   Nature aging·3 Apr 2023

1. Cold temperature increases proteasome trypsin-like activity in worms.

   “cold temperature (15 °C) selectively induces the trypsin-like activity of the proteasome in Caenorhabditis elegans through PSME-3”

   Model organismsthrough psme-315 °C

   Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

   Nature aging·3 Apr 2023

More on Proteasome trypsin-like activity