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Caloric restriction + epigallocatechin gallate

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Anhui Provincial Department of Education
  • Animals1

Outcomes

4

Microbiome composition

upin rats1

1 study

  1. Caloric restriction + epigallocatechin gallate improves microbiome composition in rats.

    “the combined intervention showed an enhanced improvement effect on the homeostasis of gut microbiota than CR alone, including increasing gut microbiota diversity and modulating microbiota composition.”

    Animalsin LepR KO rats

    Tea polyphenol EGCG enhances the improvements of calorie restriction on hepatic steatosis and obesity while reducing its adverse outcomes in obese rats

    Phytomedicine : international journal of phytotherapy and phytopharmacology9 Apr 2025

More on Microbiome composition

Inflammation

downin rats1

1 study

  1. Caloric restriction + epigallocatechin gallate decreases inflammation in rats.

    “CR plus EGCG remarkably reduced oxidative stress and systemic inflammatory responses in LepR KO rats.”

    Animalsin LepR KO rats

    Tea polyphenol EGCG enhances the improvements of calorie restriction on hepatic steatosis and obesity while reducing its adverse outcomes in obese rats

    Phytomedicine : international journal of phytotherapy and phytopharmacology9 Apr 2025

More on Inflammation

Oxidative stress and ROS signalling

downin rats1

1 study

  1. Caloric restriction + epigallocatechin gallate decreases oxidative stress and ROS signalling in rats.

    “CR plus EGCG remarkably reduced oxidative stress and systemic inflammatory responses in LepR KO rats.”

    Animalsin LepR KO rats

    Tea polyphenol EGCG enhances the improvements of calorie restriction on hepatic steatosis and obesity while reducing its adverse outcomes in obese rats

    Phytomedicine : international journal of phytotherapy and phytopharmacology9 Apr 2025

More on Oxidative stress and ROS signalling

Hepatic steatosis

downin rats1

1 study

  1. Caloric restriction + epigallocatechin gallate protects against hepatic steatosis in rats.

    “CR plus EGCG exhibited enhanced preventive effects in reducing blood glucose, insulin, TC, TG, LDL-C, and FFA levels in plasma, and protection against hepatic steatosis in LepR KO rats than CR alone.”

    Animalsin LepR KO rats

    Tea polyphenol EGCG enhances the improvements of calorie restriction on hepatic steatosis and obesity while reducing its adverse outcomes in obese rats

    Phytomedicine : international journal of phytotherapy and phytopharmacology9 Apr 2025

More on Hepatic steatosis

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