BIBR1532
- 1 lab in 1 country
- Funders: Korea University and 2 more
- Cells1
Outcomes
3Glutamate uptake
no changein human cells1
1 study
Glutamate uptake
no changein human cells1
BIBR1532 has no effect on glutamate uptake in human cells.
“Moreover, their key functional properties, such as glutamate uptake, synaptic vesicle clearance, mitochondrial membrane potential and morphology remain comparable to those of control astrocytes.”
Cellshuman pluripotent stem cell-derived astrocytes
Journal of cellular physiology1 Dec 2025
Telomere length
downin human cells1
1 study
Telomere length
downin human cells1
BIBR1532 decreases telomere length in human cells.
“accompanied by significant shortening of relative telomere length”
Cellsduring differentiationhuman pluripotent stem cell-derived astrocytes
Journal of cellular physiology1 Dec 2025
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
BIBR1532 induces cellular senescence in human cells.
“Treatment with the telomerase inhibitor BIBR1532 (BIBR) during differentiation induced hallmark features of senescence, including nuclear lamina abnormalities, enhanced senescence-associated β-galactosidase activity, increased replication arrest and DNA damage”
Cellsduring differentiationhuman pluripotent stem cell-derived astrocytes
Journal of cellular physiology1 Dec 2025
Latest
2 in 12 monthsInternational Journal of Biological Macromolecules
NRF2-TERT-ACSL4 pathway inhibits ferroptosis and regulates cytoskeletal dynamics to mitigate ovarian aging
Experiments in miceReproductive system
Journal of Cellular Physiology
Telomere Attrition-Induced Senescence in Human Pluripotent Stem Cell-Derived Astrocytes: Distinct Cellular and Functional Characteristics
Experiments in human cellsTelomerase and telomere maintenance
Cancer Letters
LKB1 inhibits telomerase activity resulting in cellular senescence through histone lactylation in lung adenocarcinoma
Experiments in animalsMechanisms