BGP-15

1. BGP-15 improves fetal viability in mice.

   “BGP-15 treatment for 3 weeks prior to conception improved on-time pre-implantation embryo development and fetal viability and increased fetal size in pregnancies sired by old males.”

   Animalspregnancies sired by old males3 weeksmales

   REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice

   Reproduction (Cambridge, England)·Aug 2, 2024

1. BGP-15 decreases mortality in mice.

   “BGP-15 treatment for 5 days prior to conception reduced sperm DNA oxidation levels and improved on-time embryo development after IVF and pup survival.”

   Animalsin offspring sired by old male mice5 daysmales

   REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice

   Reproduction (Cambridge, England)·Aug 2, 2024

1. BGP-15 decreases oxidative stress and ROS signalling in mice.

   “BGP-15 treatment for 5 days prior to conception reduced sperm DNA oxidation levels and improved on-time embryo development after IVF and pup survival.”

   Animalsin reproductively old male mice5 daysmales

   REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice

   Reproduction (Cambridge, England)·Aug 2, 2024

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1. BGP-15 decreases nephrocyte functional decline in flies.

   “treatment with BGP-15, mitigated the mitochondrial defects and nephrocyte functional decline.”

   Model organismsin flies on a high-sucrose diet

   Promoting mitochondrial dynamics by inhibiting the PINK1-PRKN pathway to relieve diabetic nephropathy

   Disease models & mechanisms·Apr 11, 2024

1. BGP-15 improves ovulation in mice.

   “antifibrosis drugs (pirfenidone and BGP-15) eliminate fibrotic collagen and restore ovulation in reproductively old and obese mice”

   Animalsin reproductively old and obese miceovaryfemales

   Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary

   Science advances·Jun 17, 2022

1. BGP-15 decreases fibrotic collagen in mice.

   “antifibrosis drugs (pirfenidone and BGP-15) eliminate fibrotic collagen and restore ovulation in reproductively old and obese mice”

   Animalsin reproductively old and obese miceovaryfemales

   Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary

   Science advances·Jun 17, 2022

More on Fibrotic collagen