APELIN-13
Intervention1 paper3 findingsPubChem 25078060ChEBI 80131
- Animals1
Outcomes
3TGF-β signalling
downin mice1Very low certainty
1 study
TGF-β signalling
downin mice1Very low certainty
APELIN-13 inhibits TGF-β signalling in mice.
“lower pro-TGF-β1 expression and SMAD3 phosphorylation”
Animalspost-ischemia/reperfusion acute kidney injuryapelin-13kidney2 weeksmales
Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury · Biomedicines · 10 Sep 2026
Collagen deposition
downin mice1Very low certainty
1 study
Collagen deposition
downin mice1Very low certainty
APELIN-13 decreases collagen deposition in mice.
“reduced collagen deposition accompanied by lower pro-TGF-β1 expression and SMAD3 phosphorylation”
Animalspost-ischemia/reperfusion acute kidney injuryapelin-13kidney2 weeksmales
Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury · Biomedicines · 10 Sep 2026
Renal fibrosis
downin mice1Very low certainty
1 study
Renal fibrosis
downin mice1Very low certainty
APELIN-13 decreases renal fibrosis in mice.
“Apelin-13 pretreatment attenuated renal injury and fibrotic remodeling in aged mice”
Animalspost-ischemia/reperfusion acute kidney injuryapelin-13kidney2 weeksmales
Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury · Biomedicines · 10 Sep 2026