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Antioxidant

Intervention

4 papers4 findings

PubChem 93405

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 3 independent labs in 3 countries
  • Funders: National Institutes of Health and others
  • Model organisms1
  • Cells2

Outcomes

4

Lifespan

upin worms1

1 study

  1. Antioxidant improves lifespan in worms.

    “lifespan defects in susceptible individuals were rescued by antioxidant supplementation.”

    Model organismsin susceptible individuals upon microbial challenge

    Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions

    Aging cell1 Feb 2026

Microtubule stabilization

downin human cells1

1 study

  1. Antioxidant decreases microtubule stabilization in human cells.

    “Spindle microtubules were stabilized in fibroblasts from aged individuals, which was alleviated by antioxidant treatment.”

    Cellsin fibroblasts from aged individuals

    Human fibroblasts from aged individuals exhibit chromosomal instability through replication stress caused by oxidative stress

    npj aging25 Nov 2025

Lipid droplet accumulation

downin cells1

1 study

  1. Antioxidant decreases lipid droplet accumulation in cells.

    “antioxidant treatment attenuates iron-driven LD accumulation”

    Cellsin primary neurons with iron overload

    Labile iron overload reprograms microglia and neurons for lipid droplet synthesis in the aging brain

    bioRxiv : the preprint server for biology5 Nov 2025Preprint

Lipid droplet formation

downin cells1

1 study

  1. Antioxidant decreases lipid droplet formation in cells.

    “scavenging ROS suppresses LD formation”

    Cellsiron-driven

    Labile iron overload reprograms microglia and neurons for lipid droplet synthesis in the aging brain

    bioRxiv : the preprint server for biology5 Nov 2025Preprint

Funding

5 grants since 2022

National Institute on AgingUS$2.8mNational Heart, Lung, and Blood InstituteUS$297.8k

Latest

Nov 2025: 61Dec 2025: 73Jan 2026: 72Feb 2026: 48Mar 2026: 34Apr 2026: 1May 2026: 1Jun 2026: 2Jul 2026: 15Aug 2026: 98Sep 2026: 108Oct 2026: 16529 in 12 months
bioRxiv

Low-dose zinc improves health and stress defence in worms

In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.In aged roundworms, a low dose of zinc restored organismal zinc after an approximately 90% drop in zinc-to-sulfur ratio, improving healthspan and stress resistance.

Preprint: experiments in wormsInterventions
Paper
Antioxidants & Redox Signaling

Protein loss caused senescence-like changes in lab-grown neurons

Experiments in models of neurons that regulate energy balance found cell enlargement and other senescence-like changes after researchers removed or reduced selenoprotein…Experiments in models of neurons that regulate energy balance found cell enlargement and other senescence-like changes after researchers removed or reduced selenoprotein T.

Experiments in miceCellular senescence
Paper

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