Acidosis

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Deutsche Forschungsgemeinschaft and 3 more

Humans1
Cells1

Outcomes

Ca2+ sensitivity

downin human cells1

1 study

Acidosis decreases Ca2+ sensitivity in human cells.
“Elevated H+ and Pi shifted the force-pCa relationship to the right, confirming nonhuman studies that these metabolites contribute to fatigue by depressing the sensitivity of the myofilaments to Ca2+.”
Cellsskeletal musclepH 6.2 + 30 mM Pi
Effects of acidosis and inorganic phosphate on Ca²⁺ sensitivity of young and older adult skeletal muscle fibers
American journal of physiology. Cell physiology5 Dec 2025