Ca2+ sensitivity

1. Acidosis decreases Ca2+ sensitivity in human cells.

   “Elevated H+ and Pi shifted the force-pCa relationship to the right, confirming nonhuman studies that these metabolites contribute to fatigue by depressing the sensitivity of the myofilaments to Ca2+.”

   Cellsskeletal musclepH 6.2 + 30 mM Pi

   Effects of acidosis and inorganic phosphate on Ca²⁺ sensitivity of young and older adult skeletal muscle fibers

   American journal of physiology. Cell physiology·5 Dec 2025

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