Acetaldehyde
- 1 lab in 1 country
- Funders: Cancer Research UK and 1 more
- Humans1
- Animals1
- Model organisms1
Outcomes
1HSC pool
downin mice1
1 study
HSC pool
downin mice1
Acetaldehyde decreases HSC pool in mice (>600-fold reduction).
“there is more than a 600-fold reduction in the HSC pool of mice deficient in both Fanconi anaemia pathway-mediated DNA repair and acetaldehyde detoxification”
Animalsdeficient in both Fanconi anaemia pathway-mediated DNA repair and acetaldehyde detoxification
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
Nature26 Aug 2012
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