HSC pool
1 paper1 finding
- Animals1
Interventions
1Acetaldehyde
downin mice1
1 study
Acetaldehyde
downin mice1
Acetaldehyde decreases HSC pool in mice (>600-fold reduction).
“there is more than a 600-fold reduction in the HSC pool of mice deficient in both Fanconi anaemia pathway-mediated DNA repair and acetaldehyde detoxification”
Animalsdeficient in both Fanconi anaemia pathway-mediated DNA repair and acetaldehyde detoxification
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
Nature26 Aug 2012
Latest
3 in 12 monthsCancer Discovery
The Evolution of Polyclonal Competition in Aging Hematopoiesis
Computational studyBlood and immune system
bioRxiv
Non-Canonical Heme Oxygenase-1 Function in Hematopoietic Stem Cell Homeostasis and Aging
Preprint: experiments in miceStem cell maintenance
bioRxiv
Plcl1 Regulates Hematopoietic Stem Cell Function During Aging and Stress by Modulating Calcium Dynamics
Preprint: experiments in animalsStem cell maintenance
Nature Aging
Aberrant engagement of P-selectin drives hematopoietic stem cell aging in mice
Experiments in miceBlood and immune system
Biochemical and Biophysical Research Communications
Proteomic characterization of murine hematopoietic stem progenitor cells reveals dynamic fetal-to-adult changes in metabolic-related pathways
Experiments in cellsOxidative phosphorylation