ABT-737

Intervention Senolytics

1 paper

Animals1

Latest

2 in 12 months

Anticancer Research30 Jan

Targeted Sensitization of Leukemic T-cells to Anticancer Drugs by SIRT1 Agonist SRT-1720

Experiments in cellsInterventions

bioRxiv1 Dec

Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis

Preprint: experiments in animalsApoptosis

Journal of Medicinal Chemistry20 Oct

Discovery of Novel PI3K/BRD4 Dual Inhibitors for Esophageal Cancer: Rational Design, Optimization, and Senescence-Inducing Mechanisms

Experiments in miceEsophageal cancer

Critical Reviews in Oncology/hematology17 Aug

Role of Bcl-2 family anti-apoptosis inhibition in overcoming therapeutic resistance in prostate cancer: A systematic review

ReviewInterventions

Nature Aging15 Jul

Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice

Experiments in animalsMechanisms

Aging Cell8 Jul

Senescent Microglia Mediate Neuroinflammation-Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

Experiments in animalsInterventions

Biomolecules26 Jun

Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Experiments in cellsInterventions

Experimental Dermatology23 Jan

Senolytic Targeting of Anti-Apoptotic Bcl Family Increases Cell Death in UV-Irradiated Senescent Melanocytes: Search for Senolytics

Experiments in cellsInterventions