Esophageal cancer

1. Esophageal cancer increases disease incidence in humans (APC: 4.86% (95% CI: 3.01-6.73)).

   Humansin China from 2020 to 20232020 to 2023

   Trends and Projections of Esophageal Cancer Incidence and Mortality in China, 1990 to 2050: An Analysis of the Global Burden of Disease Study 2023 · Journal of clinical gastroenterology · 6 Oct 2026

2. Esophageal cancer decreases disease incidence in humans (AAPC -2.56% (95% CI: -3.00 to -2.13)).

   Humansin China from 1990 to 20231990 to 2023

   Trends and Projections of Esophageal Cancer Incidence and Mortality in China, 1990 to 2050: An Analysis of the Global Burden of Disease Study 2023 · Journal of clinical gastroenterology · 6 Oct 2026

1. Esophageal cancer decreases mortality in humans (AAPC -2.94% (95% CI: -5.36 to -0.47)).

   Humansin China from 1990 to 20231990 to 2023

   Trends and Projections of Esophageal Cancer Incidence and Mortality in China, 1990 to 2050: An Analysis of the Global Burden of Disease Study 2023 · Journal of clinical gastroenterology · 6 Oct 2026

1. Jiangsu Province cancer registry data (2010-2021) decreases esophageal cancer in humans.

   Humans2010-2021

   Trends and future burden of major digestive system cancers in Jiangsu Province, China, 2010-2030 · Frontiers in oncology · 9 Sep 2026

1. Alcohol-related liver disease raises the risk of esophageal cancer in humans (IRR 5.98).

   Humansn = 43,994

   Differential Cancer Risks and Noninvasive Predictors in MASLD, MetALD, and ALD: A Longitudinal Analysis · Gut and liver · 15 Sep 2026

Alcohol-related liver disease →

1. Iron deficiency is associated with esophageal cancer in humans (RR=1.31, 95% CI: 1.14-1.52).

   Humans1990-2021

   Spatiotemporal co-occurrence patterns and related risk factors of esophageal and lip and oral cavity cancers among older adults across 203 countries and territories: a machine learning-driven systematic analysis · Annals of medicine · 4 Sep 2026

Iron deficiency →

1. Alcohol raises the risk of esophageal cancer in humans (RR=1.32, 95% CI: 1.13-1.53).

   Humanshigh alcohol use1990-2021

   Spatiotemporal co-occurrence patterns and related risk factors of esophageal and lip and oral cavity cancers among older adults across 203 countries and territories: a machine learning-driven systematic analysis · Annals of medicine · 4 Sep 2026

Alcohol →