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Compound 23

Intervention

1 paper2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Chinese Academy of Medical Sciences and 1 more
  • Animals1

Outcomes

2

Proliferation

downin human cells1

1 study

  1. Compound 23 inhibits proliferation in human cells.

    “In vitro, 23 inhibited proliferation, migration, invasion, and colony formation of esophageal cancer cells.”

    Cellsin vitro

    Discovery of Novel PI3K/BRD4 Dual Inhibitors for Esophageal Cancer: Rational Design, Optimization, and Senescence-Inducing Mechanisms

    Journal of medicinal chemistry20 Oct 2025

Esophageal cancer

downin mice1

1 study

  1. Compound 23 decreases esophageal cancer in mice.

    “In vivo, 23 demonstrated anticancer efficacy comparable to that of the BKM120/JQ1 combination treatment in a KYSE450 xenograft mouse model.”

    Animalsin a KYSE450 xenograft mouse model

    Discovery of Novel PI3K/BRD4 Dual Inhibitors for Esophageal Cancer: Rational Design, Optimization, and Senescence-Inducing Mechanisms

    Journal of medicinal chemistry20 Oct 2025

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