4-n-furfurylcytosine
- 1 lab in 1 country
- Funder: Narodowe Centrum Nauki
- Animals1
Outcomes
4mtDNA/nDNA ratio
upin mice1
1 study
mtDNA/nDNA ratio
upin mice1
4-n-furfurylcytosine increases mtDNA/nDNA ratio in mice.
“increased mtDNA:nDNA ratio”
AnimalsC57BL/6J miceLong-term
Free radical biology & medicine22 May 2026
Coordination and endurance
upin mice1
1 study
Coordination and endurance
upin mice1
4-n-furfurylcytosine improves coordination and endurance in mice.
“In aged mice, FC supplementation preserved lean body mass, improved coordination and endurance”
AnimalsC57BL/6J miceLong-term
Free radical biology & medicine22 May 2026
Oxidative damage
downin human cells1
1 study
Oxidative damage
downin human cells1
4-n-furfurylcytosine decreases oxidative damage in human cells.
“FC reduced intracellular reactive oxygen species and oxidative damage, as evidenced by decreased levels of 8-oxodG, protein carbonyls, and lipid peroxidation.”
CellsPhysiological and stress-induced senescenceMRC-5 fibroblasts and HaCaT keratinocytes
Free radical biology & medicine22 May 2026
Cellular senescence markers
downin human cells1
1 study
Cellular senescence markers
downin human cells1
4-n-furfurylcytosine decreases cellular senescence markers in human cells.
“FC enhanced cell survival and mitigated key hallmarks of senescence, including β-galactosidase activity and p16 expression.”
CellsPhysiological and stress-induced senescenceMRC-5 fibroblasts and HaCaT keratinocytes
Free radical biology & medicine22 May 2026
Associations
1Mitochondrial bioenergetic state
mixedin human cells1
1 study
Mitochondrial bioenergetic state
mixedin human cells1
4-n-furfurylcytosine is associated with mitochondrial bioenergetic state in human cells.
“FC improved mitochondrial membrane polarization and increased ATP levels while reducing oxygen consumption, indicating an altered bioenergetic state.”
CellsPhysiological and stress-induced senescenceMRC-5 fibroblasts and HaCaT keratinocytes
Free radical biology & medicine22 May 2026