Duloxetine
Duloxetine has been studied in 6 papers since 1997: 1 trial and 1 observational study in people, 3 in animals, 1 review; 2 in the past year.
None of its findings points the other way.
- 1 lab in 1 country
- 2 trials, none about aging
- Funder: National Institute on Aging
- Human trial1
- Humans1
- Animals3
What did studies of Duloxetine find?
4Studies of Duloxetine measured 4 outcomes; the most studied are depression-like behavior (1 study), bradycardia (1) and inhibitory responses to 5-HT (1).
Depression-like behavior
no changein mice1
1 study
Depression-like behavior
no changein mice1
Duloxetine has no effect on depression-like behavior in mice.
“Duloxetine and fluoxetine were ineffective in both tests.”
Animals1 monthfemales
The international journal of neuropsychopharmacology
Bradycardia
downin mice1
1 study
Bradycardia
downin mice1
Duloxetine decreases bradycardia in mice.
“Combination with duloxetine or tolterodine alleviated fingolimod induced heart rate decrease.”
Animalsfingolimod-induced heart rate decreaseheart
Impact of Age and Polytherapy on Fingolimod Induced Bradycardia: a Preclinical Study
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Inhibitory responses to 5-HT
no changein rats1
1 study
Inhibitory responses to 5-HT
no changein rats1
Duloxetine has no effect on inhibitory responses to 5-HT in rats.
“Within each age group, duloxetine co-application did not alter the inhibitory responses (IT50 values) produced by the application of 5-HT alone.”
Animalshippocampusfemales
Pharmacology
Time to recovery of baseline firing
upin rats1
1 study
Time to recovery of baseline firing
upin rats1
Duloxetine increases time to recovery of baseline firing in rats (+68%, p < 0.05).
“in the 24- to 27-month-old group a significant increase in the time to recovery of baseline firing was found with co-application of duloxetine (68%; p < 0.05)”
Animalswith continuous co-application of duloxetine (>= 5 min)hippocampusfemales
Pharmacology
Trial sponsors
Company1 trialPhase 4294 people
1 trialPhase 256 people