TIA1

1. TIA1 decreases cellular senescence in human cells.

   “ectopic expression of TIA-1 restored FUNDC1 levels, enhanced mitophagy, improved mitochondrial function, and reduced senescence marker expression.”

   Cellsectopic expression in stressed HaCaT cellskeratinocytes

   TIA-1 promotes FUNDC1-mediated mitophagy to protect against stress-induced cellular senescence

   Experimental & molecular medicine·5 Jun 2026

More on Cellular senescence

1. TIA1 activates mitophagy in human cells.

   “ectopic expression of TIA-1 restored FUNDC1 levels, enhanced mitophagy, improved mitochondrial function, and reduced senescence marker expression.”

   Cellsectopic expression in stressed HaCaT cellskeratinocytes

   TIA-1 promotes FUNDC1-mediated mitophagy to protect against stress-induced cellular senescence

   Experimental & molecular medicine·5 Jun 2026

More on Mitophagy

1. TIA1 increases FUNDC1 in human cells.

   “TIA-1 directly interacts with FUNDC1 mRNA, and subsequent analyses indicated that TIA-1 enhances FUNDC1 expression primarily through translational control.”

   Cellsstress-induced cellular senescencekeratinocytes

   TIA-1 promotes FUNDC1-mediated mitophagy to protect against stress-induced cellular senescence

   Experimental & molecular medicine·5 Jun 2026

More on FUNDC1

1. TIA1 increases behavioral deficits in mice.

   “Despite the increase in neurofibrillary tangles, TIA1 reduction increased neuronal survival and rescued behavioral deficits and lifespan.”

   Animalsin transgenic P301S Tau mice

   Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

   Nature neuroscience·20 Nov 2017

1. TIA1 increases tau oligomers in mice.

   “Decreasing TIA1 also inhibited the accumulation of tau oligomers at the expense of increasing neurofibrillary tangles.”

   Animalsin transgenic P301S Tau mice

   Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

   Nature neuroscience·20 Nov 2017

More on Tau oligomers

1. TIA1 shortens lifespan survival in mice.

   “reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo protects against neurodegeneration and prolongs survival in transgenic P301S Tau mice”

   Animalsin transgenic P301S Tau mice

   Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

   Nature neuroscience·20 Nov 2017