Tau oligomers

1 paper1 finding

Animals1

Upstream

1

TIA1

upin mice1

1 study

TIA1 increases tau oligomers in mice.
“Decreasing TIA1 also inhibited the accumulation of tau oligomers at the expense of increasing neurofibrillary tangles.”
Animalsin transgenic P301S Tau mice
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
Nature neuroscience20 Nov 2017

Latest

2 in 12 months

bioRxiv24 Sep

Soluble pathogenic tau transmission to astrocytes drives cellular senescence and neurovascular uncoupling in a model of Alzheimer's tauopathy

Preprint: experiments in miceCellular senescence

AAIC 2025 Abstract8 Jan

Brain‐Derived Tau Oligomers in Circulating Extracellular Vesicles as Predictive Biomarkers for Alzheimer's Disease Conversion

Cohort study in peopleTau

Alzheimer's & Dementia10 Oct

Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies

ReviewMechanisms

Nature Communications15 May

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

Experiments in animalsMechanisms

The Journal of Biological Chemistry10 Oct

Aging-associated REGγ proteasome decline predisposes to tauopathy

Experiments in animalsMechanisms

Nature Neuroscience20 Nov

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Experiments in miceMechanisms