α-ketoglutarate
Biomarker3 papers1 finding
- Model organisms2
- In silico1
Upstream
1Glycolysis
downin silico1
1 study
Glycolysis
downin silico1
Glycolysis decreases α-ketoglutarate in silico.
“deplete the mitochondrial alpha-ketoglutarate pool relative to 2-hydroxyglutarate and succinate”
In silico
Metabolic-Epigenetic Coupling in Cellular Senescence: In Silico Cristae Remodeling Depletes Alpha-Ketoglutarate to Drive KDM4/6 Inhibition and SASP Amplification · bioRxiv · 18 Sep 2026 · Preprint
Funding
National Institute on AgingUS$214.5k1 grant since 2026
Latest
6Research SquareAnimalsPreprint
DNA damage differed by sex in mice with impaired DNA repair
Experiments in mice with impaired DNA repair identified a female-specific metabolic pathway; a dietary supplement restored muscle force and metabolic…Experiments in mice with impaired DNA repair identified a female-specific metabolic pathway; a dietary supplement restored muscle force and metabolic profiles in females.
bioRxivModel organismsPreprint