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SURF1

Gene

6 papers7 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Ellison Medical Foundation and 8 more
  • Animals4
  • In silico1

Effects

7

Healthspan

no changein mice1

1 study

  1. SURF1 has no effect on healthspan in mice.

    “no change in healthspan indices in Surf1-/- vs. Surf1+/+ mice”

    AnimalsSurf1-/- vs. Surf1+/+

    Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

    Aging cell25 Apr 2018

Lifespan

no changein mice1

1 study

  1. SURF1 has no effect on lifespan in mice (7% median, 16% maximum).

    “We found only a modest (nonsignificant) extension of lifespan (7% median, 16% maximum) and no change in healthspan indices in Surf1-/- vs. Surf1+/+ mice”

    AnimalsSurf1-/- vs. Surf1+/+

    Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

    Aging cell25 Apr 2018

Respiratory quotient

downin mice1

1 study

  1. SURF1 decreases respiratory quotient in mice (0.83-0.93 vs. 0.90-0.98).

    “The respiratory quotient in the Surf1(-/-) mice was significantly lower than in the control animals (0.83-0.93 vs. 0.90-0.98)”

    AnimalsSurf1 deficiency

    Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology14 Dec 2012

More on Respiratory quotient

Fat mass

downin mice1−20% fat mass

1 study

  1. SURF1 decreases fat mass in mice (-20% fat mass).

    “Surf1(-/-) mice have lower body (15%) and fat (20%) mass”

    AnimalsSurf1 knockoutwhite adipose tissue

    Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology14 Dec 2012

Body weight

downin mice1−15% body mass

1 study

  1. SURF1 decreases body weight in mice (-15% body mass).

    “Surf1(-/-) mice have lower body (15%) and fat (20%) mass”

    AnimalsSurf1 knockoutwhite adipose tissue

    Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology14 Dec 2012

Mortality

upin mouse cells1

1 study

  1. SURF1 increases mortality in mouse cells.

    “reduced mortality, compared to controls”

    Cellsin primary neuronal culturesneuron

    Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

    Human molecular genetics8 Jan 2007

Neurotoxicity

upin mice1

1 study

  1. SURF1 increases neurotoxicity in mice.

    “complete protection from Ca(2+)-dependent neurotoxicity induced by kainic acid”

    Animalsinduced by kainic acid

    Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice

    Human molecular genetics8 Jan 2007

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