SMO

1. SMO inhibits ferroptosis in mice.

   “loss of hepatocyte Hedgehog signaling induces ferroptotic stress, lipid peroxidation, and cellular senescence.”

   Animalsshown by hepatocyte-specific deletionliver

   Hepatocyte hedgehog signaling controls ferroptosis to alleviate aging-related organ dysfunction

   JCI insight·19 May 2026

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1. SMO decreases disordered chondrocyte-like cells in mice.

   “conditional ablation of Smo, an essential transducer of Hh signaling, in adult discs accelerated degeneration and promoted both NP-derived (Krt19+ N-CLCs) and non-NPC-derived (Krt19− D-CLCs) populations.”

   Animalsconditional ablation of Smointervertebral disc

   Dual-Lineage Chondrocyte-Like Cells in the Nucleus Pulposus of Aging Intervertebral Discs Are Accelerated by Hedgehog Signaling Inactivation

   Aging cell·22 Sep 2025

More on Disordered chondrocyte-like cells

1. SMO protects against intervertebral disc degeneration in mice.

   “conditional ablation of Smo, an essential transducer of Hh signaling, in adult discs accelerated degeneration”

   Animalsconditional ablation in adult discsintervertebral disc

   Dual-Lineage Chondrocyte-Like Cells in the Nucleus Pulposus of Aging Intervertebral Discs Are Accelerated by Hedgehog Signaling Inactivation

   Aging cell·22 Sep 2025

More on Intervertebral disc degeneration