Disordered chondrocyte-like cells

1. SMO decreases disordered chondrocyte-like cells in mice.

   “conditional ablation of Smo, an essential transducer of Hh signaling, in adult discs accelerated degeneration and promoted both NP-derived (Krt19+ N-CLCs) and non-NPC-derived (Krt19− D-CLCs) populations.”

   Animalsconditional ablation of Smointervertebral disc

   Dual-Lineage Chondrocyte-Like Cells in the Nucleus Pulposus of Aging Intervertebral Discs Are Accelerated by Hedgehog Signaling Inactivation

   Aging cell·22 Sep 2025

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