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SMARCA4

Gene

2 papers3 findings

HGNCMGINCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Humans1
  • Animals1

Effects

2

Peritoneal fibrosis

upin mice1

1 study

  1. SMARCA4 increases peritoneal fibrosis in mice.

    “In a mouse PD model, BRG1 knockdown restored mitophagy, alleviated senescence and ameliorated peritoneal fibrosis.”

    Animalsin a mouse PD model

    BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1

    Free radical biology & medicine2 Feb 2024

More on Peritoneal fibrosis

Cellular senescence

upin mouse cells1

1 study

  1. SMARCA4 increases cellular senescence in mouse cells.

    “The augmentation of BRG1 expression accelerated peritoneal mesothelial cell senescence, which attributed to mitochondrial dysfunction and mitophagy inhibition.”

    CellsBRG1 expression augmentation

    BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1

    Free radical biology & medicine2 Feb 2024

More on Cellular senescence

Associations

1

D/P creatinine

upin humans1

1 study

  1. SMARCA4 is associated with D/P creatinine in humans.

    “elevation level of BRG1 in human PD was associated with PD duration and D/P creatinine values.”

    Humanshuman PD patients

    BRG1 accelerates mesothelial cell senescence and peritoneal fibrosis by inhibiting mitophagy through repression of OXR1

    Free radical biology & medicine2 Feb 2024

More on D/P creatinine

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