OXR1
Gene1 paper4 findings
- Animals1
Effects
4KEAP1 association with P62/SQSTM1
upin mouse cells1
1 study
KEAP1 association with P62/SQSTM1
upin mouse cells1
OXR1 increases KEAP1 association with P62/SQSTM1 in mouse cells.
Cellsosteoclast
Targeting a cell regulator reduced bone loss in mice · Nature communications · 5 Sep 2026
Osteoclast formation
upin mice1
1 study
Osteoclast formation
upin mice1
OXR1 increases osteoclast formation in mice.
Animalsshown by myeloid-specific loss of Oxr1
Targeting a cell regulator reduced bone loss in mice · Nature communications · 5 Sep 2026
Autophagy
upin mouse cells1
1 study
Autophagy
upin mouse cells1
OXR1 increases autophagy in mouse cells.
Cellsshown by Oxr1 knockdownosteoclast precursor
Targeting a cell regulator reduced bone loss in mice · Nature communications · 5 Sep 2026
Reactive oxygen species
downin mouse cells1
1 study
Reactive oxygen species
downin mouse cells1
OXR1 decreases reactive oxygen species in mouse cells.
Cellsshown by Oxr1 knockdownosteoclast precursor
Targeting a cell regulator reduced bone loss in mice · Nature communications · 5 Sep 2026
Funding
National Institute on AgingUS$809.5k1 grant since 2026
Latest
1Targeting a cell regulator reduced bone loss in mice
In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.