There is 1 paper on NUR77 in aging research: none in people yet, 1 in animals.
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funder: National Natural Science Foundation of China
- Animals1
Effects
4Aging-related nephropathy
upin mice1
1 study
Aging-related nephropathy
upin mice1
NUR77 increases aging-related nephropathy in mice (shown by Nur77 deficiency).
“Nur77 deficiency markedly aggravated aging-related nephropathy”
Animalsshown by Nur77 deficiencykidney
Aging cell
Lifespan
downin mice1
1 study
Lifespan
downin mice1
NUR77 shortens lifespan in mice (shown by deletion).
“Deletion of Nr4a1 shortened the lifespan and accelerated the aging process in multiple mouse tissues.”
Animalsshown by deletion
Aging cell
MDM2
downin mouse cells1
1 study
MDM2
downin mouse cells1
NUR77 inhibits MDM2 in mouse cells (shown by overexpression).
“through negative transcriptional regulation of the E3 ligase MDM2”
Cellsshown by overexpression
Aging cell
SIRT1PROTEIN
upin mouse cells1
1 study
SIRT1PROTEIN
upin mouse cells1
NUR77 increases SIRT1PROTEIN in mouse cells (shown by overexpression; protection from proteasomal degradation).
“Overexpression of Nr4a1 protected the Sirt1 protein from proteasomal degradation through negative transcriptional regulation of the E3 ligase MDM2”
Cellsshown by overexpression; protection from proteasomal degradation
Aging cell
Upstream
1Oxidative stress and ROS signaling
downin mouse cells1
1 study
Oxidative stress and ROS signaling
downin mouse cells1
Oxidative stress and ROS signaling decreases NUR77 in mouse cells (oxidative stress-induced cell senescence).
“Nur77 and Sirt1 decreased during aging and oxidative stress-induced cell senescence”
Cellsoxidative stress-induced cell senescence
Aging cell